Skin Repair, Regeneration and Pigmentation

Reviewed July 7, 2016

Research Areas

This program consists of two components: 1) Epidermal Repair and Regeneration; 2) Melanocyte Biology. Basic, translational and clinical studies of these two areas of research are covered by this program.

Aspects of keratinocyte behavior during the wound healing process (e.g., proliferation, migration, cytokine response and regulation) comprise a major part of this program. Basic studies of the normal and abnormal epithelial wound healing process are another focus of the program. The program also contains translational and clinical studies on treating chronic wound, ranging from animal model creation, devise testing and clinical trials. The program also reflects an increasing use of epithelial and mesenchymal stem cells in treating chronic wound and tissue engineering, and artificial tissue/organ construction in epidermal regeneration.

The Melanocyte Biology component includes studies of normal melanocyte development, differentiation, maintenance, regulation and the pigmentation process of skin and its appendages. An emerging area of research is melanocyte stem cell identification and its regulation. In general, melanoma studies (i.e., tumorigenesis, metastasis and treatment) are not part of the NIAMS Melanocyte Biology Program. However, studies concerning the prevention of melanocyte tumorigenesis are considered within the mission of the program. Autoimmunity caused pigmentation deficiency is considered in the NIAMS Skin Immunity Program, and is not included in the Melanocyte Biology Program.

Staff Contact:

Hung Tseng, Ph.D.
Program Director
Skin Repair, Regeneration and Pigmentation Program
Division of Skin and Rheumatic Diseases
One Democracy Plaza
6701 Democracy Blvd., Ste. 800
Bethesda, MD 20892-4872