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Research in NIAMS Labs
Updated February 1, 2016
NIAMS Laboratory Has New Paper on Histone Variants
MacroH2A1.2 is a histone variant required for activation of regulatory networks that control gene expression. New research from the Sartorelli lab reveals that macroH2A1.2 marks the regulatory regions for gene activation in muscle cells and serves as a guide for chromatin recruitment of Pbx1 and subsequent binding of MyoD.
Research Identifies Factors Contributing to Autoimmunity
A new paper from Dr. Mariana Kaplan, chief of the Systemic Autoimmunity Branch, identifies a novel role for reactive oxygen species generated by the mitochondria, as well as for oxidation of mitochondrial DNA, in the generation of abnormal neutrophil responses and promotion of autoimmunity in systemic lupus erythematosus. This may lead to the identification of new targets for future treatments for this disease.
Dr. Olivier Duverger Selected as 2015 FASEB BioArt Winner
Dr. Olivier Duverger, staff scientist in the Developmental Skin Biology Section, is among the winners of the 2015 FASEB BioArt Competition. The FASEB BioArt Competition showcases the artistic side of biomedical research images. Dr. Duverger’s winning image (left) is a scanning electron micrograph displaying the lattice structure formed by enamel rods, the building blocks of tooth enamel.
Dr. Mariana Kaplan receives Evelyn V. Hess Award
Congratulations to Dr. Mariana Kaplan, Chief of the Systemic Autoimmunity Branch, who was selected as the recipient of the 2015 Evelyn V. Hess Award by the Lupus Foundation of America. This award is presented to individuals who have made significant contributions to lupus research, diagnosis, and treatment. NIAMS is proud of Dr. Kaplan for this outstanding achievement.
NIAMS Scientist Selected as Visiting Professor
Dr. Yuka Kanno, staff scientist in the Molecular Immunology and Inflammation Branch, was invited to Paris to give a lecture to students and faculty of the Vaccine Research Institute at University of Paris-Est Créteil. Dr. Kanno visited the university on October 19th to give a lecture on epigenetics/transcriptional memory and vaccination.
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Clinical and Translational Research
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- Superior Athleticism: Is It in Your Genes?
- NIH Researchers Reveal Link Between Powerful Gene Regulatory Elements and Autoimmune Diseases