TABLE 1: TNF superfamily Ligands

LocusLink ID	Symbol	Common name	Position	Aliases	Binds to Receptor(s)	OMIM ID	Key Functions	Phenotype associated with overexpression	Phenotype associated with deficiency	Human Genetic Diseases
4049	TNFSF1	Lymphotoxin alpha (Lta)	6p21.3	LT, TNFB, TNFSF1	TNFR2 (1B), TNFR1 (1A), HVEM (14)	153440	lymphoid organ formation		Absence of LN and PP, defective GC formation
7124	TNFSF2	tumor necrosis factor (TNF)	6p21.3	DIF, TNFA, TNFSF2, CACHECTIN	TNFR2 (1B), TNFR1 (1A)	191160	inflammation	Wasting syndrome, arthritis	defective GC formation, resistance to endotoxic shock and experimental arthritis	TNF2 (G-308A) promotor polymorphism associated with increased susceptability to septic shock. asthma and RA severity
4050	TNFSF3	lymphotoxin beta (LTb)	6p21.3	p33, TNFC, TNFSF3	as a b2a1 heterotrimer with LT-a binds to LT-b Receptor (3)	600978	lymphoid organ formation	Ectopic lymphoid organ formation
7292	TNFSF4	OX40 Ligand	1q25	GP34, OX4OL, TXGP1, CD134L, OX-40L	OX40 (4)	603594	CD4 T cell expansion, survival, and Th2 development	Increased Th2 responses	Th2 deficiency, blockade improves EAE
959	TNFSF5	CD40 Ligand	Xq26	IGM, IMD3, TRAP, gp39, CD154, CD40L, HIGM1, T-BAM,	CD40 (5)	300386	Costimulation and differentiation of B cells and APC	Constitutive expression in B cells or keratinocytes leads to SLE-like syndrome	Immunodeficiency due to Defective Ig class switching and germinal center formation	X-linked hyper-IGM syndrome associated with CD40L loss of function mutations
356	TNFSF6	Fas Ligand	1q23	FASL, CD178, CD95L, APT1LG1	Fas (6), DcR3 (6B)	134638	Mediator of CD4(+) T cell apoptosis due to restimulation and apoptosis in other cell types		Lymphadenopathy and Systemic Autoimmunity	Autoimmune Lymphoproliferative Syndrome (ALPS) type Ib
970	TNFSF7	CD27 Ligand	19p13	CD70, CD27L, CD27LG	CD27 (7)	602840	T cell costimulation	T cell hyperactivation eventually leading to immunodeficiency (HIV-like)
944	TNFSF8	CD30 Ligand	9q33	CD153, CD30L, CD30LG	CD30 (8)	603875
8744	TNFSF9	4-1-BB Ligand	19p13.3	4-1BB-L	4-1BB (9)	606182	T cell costimulation
8743	TNFSF10	(TNF-like apoptosis inducing ligand)TRAIL	3q26	TL2, APO2L, TRAIL, Apo-2L	DR4 (10A), DR5 (10B), DcR1 (10C), DcR2 (10D)	603598	Dendritic cell apoptosis, NK-cell mediated tumor cell killing		defective NK-mediated tumor eradication
8600	TNFSF11	RANK-L	13q14	ODF, OPGL, sOdf, RANKL, TRANCE, hRANKL2	RANK (11A)	602642	mediates osteoclast formation and bone remodeling. Stimulation of APC
8742	TNFSF12	TWEAK	17p13	APO3L, DR3LG, TWEAK, MGC20669	TWEAK-R (12A)	602695	Potential role in inflammation and lymphocyte function
8741	TNFSF13	APRIL	17p13.1	APRIL, TALL2, TWE-PRIL	TACI (13B), BCMA (17)	604472	Promotes T-independent type-2 responses through interactions with TACI	overexpression in T cells produces prolonged T cell survival and enhanced TI-2 responses
10673	TNFSF13B	BlyS, BAFF	13q32-34	BAFF, BLYS, TALL1, THANK, ZTNF4	TACI (3B), BAFF-R (13C), BCMA(17),	603969	promotes B cell maturation, plasmablast survival	SLE-like systemic autoimmunity and arthritis
8740	TNFSF14	LIGHT	19p13.3	LTg, TR2, HVEML, LIGHT	HVEM (14), LT-bR (3), DcR3 (6B)	604520	CD8 T cell and APC costimulation,	inflammation, T cell hyperactivation Th1 bias	defective CD8 T cell costimulation
9966	TNFSF15	TL1A	9q32	TL1, TL1A, VEGI	DR3 (25)	604052	Recently identified ligand for DR3 (TNFRSF25)		Blockade impairs T Cell-mediated immunopathology
8995	TNFSF18	GITR Ligand	1q23	TL6, AITRL, GITRL, hGITRL	GITR (18)	603898	T cell costimulation (+)CD25(+) regulatory T cells
1896	ED1	ectodermal dysplasia 1, anhidrotic (EDA1)	X	EDA, HED, EDA1, XHED, XLHED	EDAR	305100	Tooth, hair and Sweat gland formation			X-LINKED ECTODERMAL DYSPLASIA

TABLE 2: TNF superfamily Receptors

LocusLink ID	Symbol	Common Name(s)	Position	Aliases	Binds to Ligand(s)	OMIM ID	Key Functions	Phenotype associated with deficiency	Human Genetic Diseases
7132	TNFRSF1A	tumor necrosis factor receptor 1 (TNF-R1)	12p13.2	FPF, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55, MGC19588	TNFa (2), Lta (1)	191190	Mediates TNF-induced inflammation (and apoptosis in some cells)	resistance to TNF-induced artrhritis models, resistant to endotoxic shock, Increased sensitivity to bacterial pathogens	Periodic fever syndrome(TRAPS)associated with heterozygous extracellular mutaions
7133	TNFRSF1B	tumor necrosis factor receptor 2 (TNF-R2)	1p36.3-p36.2	p75, TBPII, TNFBR, TNFR2, CD120b, TNFR80, TNF-R75, p75TNFR, TNF-R-II	TNFa (2), Lta (1)	191191	May enhance pro-apoptotic effect of TNFR1	still susceptible to TNF-induced arthritis models, defective CD8(+) T cell apoptosis after restimulation, Increased sensitivity to bacterial pathogens
4055	TNFRSF3	lymphotoxin beta receptor	12p13	LTBR, CD18, TNFCR, TNFR-RP, TNFRSF3, TNFR2-RP, LT-BETA-R, TNF-R-III	LIGHT (14), LTb (3)	600979	lymphoid organ formation	No LN, PP, defective GC formation
7293	TNFRSF4	OX40	1p36	OX40, ACT35, CD134, TXGP1L	OX40L (4)	600315	T cell costimulation	Defective CD4 T cell responses
958	TNFRSF5	CD40