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Research
- Branch Overview
- Chemical Immunology Section
- Genomic Integrity and Immunity Group
- Lymphocyte Cell Biology Section
- Molecular Inflammation Section
Molecular Immunology and Inflammation Branch
Scientific Director
Phone: 301-496-2612
Fax: 301-402-0012
Building: 10, Room: 6N204
E-mail: osheajo@mail.nih.gov
After receiving a Bachelor of Science from St. Lawrence University and a Doctor of Medicine degree from the University of Cincinnati, Dr. O'Shea served as a resident in Internal Medicine at the State University of New York-Upstate Medical Center in Syracuse. He came to the NIH in 1981 for subspecialty training in Allergy and Immunology in the National Institute of Allergy and Infectious Diseases. He did additional postdoctoral work in the Cell Biology and Metabolism Branch in the National Institute of Child Health and Human Development. He started his own group in the National Cancer Institute in 1989 and then moved to the National Institute of Arthritis and Musculoskeletal and Skin Diseases in 1994 as Chief of the Lymphocyte Cell Biology Section of the Arthritis and Rheumatism Branch.
He has served on the editorial boards of several journals including: Journal of Biological Chemistry, Journal of Immunology, and Blood. Presently, he is associate editor of the Journal of Biological Chemistry and Arthritis Research. He is a member of several professional societies, including the American Society for Clinical Investigation, the American Association of Immunologists, American Society for Biochemistry and Molecular Biology and the American College of Rheumatology. Dr. O'Shea has been an ad hoc member of the Ad Hoc member NIH Experimental Immunology and Immunobiology NIH and the Arthritis Foundation Study Sections. He is on the American College of Rheumatology Abstract Selection Committee and served as a Howard Hughes Medical Institute Scholars Advisor. Dr. O'Shea has been an invited lecturer at numerous universities and international meetings in the U.S., Canada, Europe and Asia.
Dr. O'Shea has received a number of awards, including the U.S. Public Health Service Physician Researcher of the Year and the National Institutes of Health Director's Award.
Dr. O'Shea is one of the course directors for Immunology 521.
Other NIAMS Affiliations
Lymphocyte Cell Biology SectionOffice of the Clinical Director
Office of the Scientific Director
Selected Publications
Ghoreschi K, Laurence A, O'Shea JJ. Selectivity and therapeutic inhibition of kinases: to be or not to be?. Nat Immunol. 2009 Apr;10(4):356-60. Epub 2009 Mar 19. Review.
McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, McClanahan TK, O'Shea JJ, Cua DJ. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing e ffector T helper cells in vivo. Nat Immunol. 2009 Mar;10(3):314-24. Epub 2009 Feb 1.
Ghoreschi K, Laurence A, O'Shea JJ. Janus kinases in immune cell signaling. Immunol Rev. 2009 Mar;228(1):273-87.
Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med. 2009 Jan 16;206(1):35-41.
Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ, Zhao K. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity. 2009 Jan;30(1):155-67.
Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, Jankovic D, Tsichlis PN, O'Shea JJ. Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. J Exp Med. 2008 Nov 24;205(12):2803-12.
Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature. 2008 Aug 13.
Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O'Shea JJ, Shevach EM. CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med. 2008 Sep 1;205(9):1975-81. Epub 2008 Aug 18.
Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, Kanno Y, Spalding C, Elloumi HZ, Paulson ML, Davis J, Hsu A, Asher AI, O'Shea J, Holland SM, Paul WE, Douek DC. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature. 2008 Apr 10;452(7188):773-6. Epub 2008 Mar 12.
Tamura T, Tailor P, Yamaoka K, Kong HJ, Tsujimura H, O'shea JJ, Singh H, Ozato K. IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol. 2005; 174(5):2573-81.
Pesu M, Candotti F, Husa M, Hofmann SR, Notarangelo LD, O'Shea JJ. Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs. Immunol Rev. 2005; 203:127-42.
O'Shea JJ, Kanno Y, Chen X, Levy DE. Cell signaling. Stat acetylation--a key facet of cytokine signaling? Science. 2005; 307(5707): 217-8.
O'Shea JJ, Pesu M, Borie DC, Changelian PS. A new modality for immunosuppression: targeting the JAK/STAT pathway. Nat Rev Drug Discov. 2004; 3(7):555-64.
Moriguchi M, Hissong BD, Gadina M, Yamaoka K, Tiffany HL, Murphy PM, Candotti F, O'shea JJ. CXCL12 signaling is independent of Jak2 and Jak3. J Biol Chem. 2004; [Epub ahead of print]
