You are here:
STATs Shape the Active Enhancer Landscape of T Cell Populations
This is the supplemental material for STATs Shape the Active Enhancer Landscape of T Cell Populations. Vahedi G, Takahashi H, Nakayamada S, Sun HW, Sartorelli V, Kanno Y and O'Shea JJ. Cell. 2012.
Correspondence should be addressed to Yuka Kanno at kannoy@mail.nih.gov.
For persons using assistive technology that may not be able to fully access information in the files linked below, or any researcher who needs assistance with accessibility for these data files please contact Gaia Vasiliver-Shamis at vasilivershamg@mail.nih.gov..
For readers who need assistance with accessibility issues on any NIAMS website not related to this Supplementary Data, please contact the NIAMS Section 508 Coordinator, Susan Bettendorf, at bettends@mail.nih.gov.
Description:
The study revealed that signal transducer and activator of transcription (STAT) proteins exert a major impact on the acquisition of active regulatory enhancers. The results were published in Cell.
Raw Data
The ChIP-seq and RNA-seq data are deposited in GEO under accession GSE40463.
p300 Related Peaks
- Th1 unique p300 peaks
- Stat1 dependent p300 peaks
- Stat4 dependent p300 peaks
- Th2 unique p300 peaks
- Stat6 dependent p300 peaks q)
- p300 peaks that are directly STAT4 dependent in a negative manner
- p300 peaks that are directly STAT4 dependent in a positive manner
- p300 peaks that are directly STAT6 dependent in a negative manner
- p300 peaks that are directly STAT6 dependent in a positive manner
- p300 peaks that are directly Tbet dependent in a negative manner
- p300 peaks that are directly Tbet dependent in a positive manner
- Stat4 dependent p300 peaks not recovered after T-bet overexpression
- Stat4 dependent p300 peaks recovered after T-bet overexpression
- Stat6 dependent p300 peaks not recovered after Gata3 overexpression
- Stat6 dependent p300 peaks recovered after Gata3 overexpression
List of Genes Based on RNA-seq Data
Gene expression values are log2(rpkm)
- 100 most differentially regulated genes in Th1 cells compared to Th2 cells
- 100 most differentially regulated genes in Th2 cells compared to Th1 cells
- 100 housekeeping genes
- Stat6 dependent genes recovered by GATA3 overexpression
- Stat6 dependent genes not recovered by GATA3 overexpression
- Stat4 dependent genes
- Stat6 dependent genes
- Tbet dependent genes
- Stat4 dependent genes recovered by Tbet overexpression
- Stat4 dependent genes not recovered by Tbet overexpression
Updated November 26, 2012




