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Orthopaedics Research Group
The Orthopaedics Research Group (ORG) focuses on understanding specific orthopaedic pathologies, to better facilitate clinical transition of lab results to medical therapies. One core ongoing project investigates heterotopic ossification (HO) — a disease prevalent in soldiers who have sustained traumatic extremity injuries — identifying promising biomolecular targets for future treatments, as well as possible markers for gauging genetic susceptibility in patients who experience physical trauma. Another aspect of ORG research centers on a novel population of multipotent mesenchymal progenitor cells (MPCs) that can be extracted in high concentrations from surgical waste tissue following musculoskeletal trauma. These MPCs are capable of coordinating regenerative mechanisms, as well as differentiating into cell types native to the musculoskeletal system, making them highly attractive for clinical use and tissue replacement strategies. Other ORG active research areas include interrogation of genetic events and epigenetic profiles associated with the healing response, bioengineering scaffolds to influence musculoskeletal regeneration, and in situ surgical capture and application of MPCs to assist wound healing.
Jackson WM, Lozito T, Djouad F, Kuhn NZ, Nesti LJ, Tuan RS. Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. J Cell Mol Med. 2010 Dec 3.
Nesti LJ, Jackson WM, Shanti RM, Koehler SM, Aragon AB, Bailey JR, Sracic MK, Freedman BA, Giuliani JR, Tuan RS. Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissue. J Bone Joint Surg Am. 2008 Nov;90(11):2390-8.
Nesti LJ, Li WJ, Shanti RM, Jiang YJ, Jackson W, Freedman BA, Kuklo TR, Giuliani JR, Tuan RS. Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam. Tissue Eng Part A. 2008 Sep;14(9):1527-37.See extended list of publications
Reviewed September 24, 2012