Research

Photo of Dr. Richard Siegel and staff member conducting research.

Immunoregulation Group

Complete list of publications

Adriani, M., Aoki, J., Horai, R., Thornton, A.M., Konno, A., Kirby, M., Anderson, S.M., Siegel, R.M., Candotti, F., Schwartzberg, P.L. (2007) Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol, 124(1):41-8.

Lilit Garibyan, Adrian A. Lobito, Richard M. Siegel, Matthew E. Call, Kai W. Wucherpfennig, and Raif S. Geha. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J. Clin Invest. 2007 June 1; 117(6): 1550–1557.

Heiyoung Park, Kabir Teja, John J. O’Shea, and Richard M. Siegel. (2007) The Yersinia effector protein YpkA induces apoptosis independently of actin depolymerization. J. Immunol, 178: 6426-34.

Laurence A*, Tato CM*, Davidson TS*, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L, Shevach EM, O'Shea JJ. *Joint first authorship Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation. Immunity. 2007 Mar;26(3):371-81.

Liu, E.H., Siegel, R.M., Harlan, D.M., and O'Shea, J.J. 2007. T cell-directed therapies: lessons learned and future prospects. Nat Immunol 8: 25-30.

Madhu Ramaswamy, Celine Dumont, Anthony C. Cruz, Jagan R. Muppidi, Timothy S. Gomez, Daniel D. Billadeau, Victor L.J. Tybulewicz, and Richard M. Siegel. (2007) Cutting Edge: Rac GTPases sensitize activated T cells to die via Fas. J. Immunol, in press.

Adrian F. Arechiga, Bryan D. Bell, Sabrina Leverrier, Brian M. Weist, Melissa Porter, Zhengqi Wu, Yuka Kanno, Stephanie J. Ramos,*S. Tiong Ong, Richard Siegel, and Craig M. Walsh. A Fas-Associated Death Domain Protein/Caspase-8-Signaling Axis Promotes S-Phase Entry and Maintains S6 KinaseActivity in T Cells Responding to IL-2, J. Immunol, in press.

Muppidi, J.R., A.A. Lobito, M. Ramaswamy, J.K. Yang, L. Wang, H. Wu, and R.M. Siegel. 2006. Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis. Cell Death Differ. 13:1641-1650.

Lobito, A.A., F.C. Kimberley, J.R. Muppidi, H. Komarow, A.J. Jackson, K.M. Hull, D.L. Kastner, G.R. Screaton, and R.M. Siegel. 2006. Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS). Blood.108:1320-7.

Wu, X., J. Simone, D. Hewgill, R. Siegel, P.E. Lipsky, and L. He. 2006. Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe. Cytometry A. 69:477-86.

He, L., X. Wu, R. Siegel, and P.E. Lipsky. 2006. TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB. J Biol Chem. 281:11235-49.

Siegel, R.M. Caspases at the crossroads of immune-cell life and death. Nature Reviews Immunology (2006) 6:308-17.

Irene C. B. Vioritto, Nikolay Nikolov, and Richard M. Siegel. 2006. Autoimmunity versus Tolerance: can dying cells tip the balance? Clinical Immunology, 122: 125-134

Muppidi JR, Tschopp J, Siegel RM. Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity. 2004; 21(4):461-5.

Wu Z, Roberts M, Porter M, Walker F, Wherry EJ, Kelly J, Gadina M, Silva EM, DosReis GA, Lopes MF, O'Shea J, Leonard WJ, Ahmed R, Siegel RM. Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. J Immunol. 2004; 172(10): 6313-23.

Muppidi JR, Siegel RM. Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat Immunol. 2004; 5(2): 182-9.

Siegel RM, Muppidi J, Roberts M, Porter M, Wu Z. Death receptor signaling and autoimmunity. Immunol Res. 2003; 27(2-3):499-512.

Siegel RM, Chan FC, Chun H, Lenardo MJ. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nature Immunology. 2000; 1: 469-474.

Siegel RM, Frederiksen JK, Zacharias DA, Chan, FC, Johnson M, Lynch, D, Tsien R, Lenardo, MJ. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science. 2000; 288: 2354.

Siegel RM, Chan, FC, Zacharias, DA, Swofford, R, Holmes, KL, Tsien, RY, Lenardo, MJ. Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein. Sci STKE. 2000 Jun 27; 2000 (38):PL1.

Siegel RM, Martin DA, Zheng L, Ng SY, Bertin J, Cohen J, and Lenardo MJ. Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis. J Cell Biol. 1998; 141: 1243-53.

Updated September 17, 2007