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Autoimmunity Branch

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Richard Siegel, M.D., Ph.D.
Chief, Autoimmunity Branch
Phone: (301) 496-5767
Fax: (301) 480-3880

Autoimmunity is a central feature of many rheumatic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. The Autoimmunity Branch was established to address the cellular and molecular basis of autoimmunity. A number of work groups have been established within the Autoimmunity Branch to investigate specific aspects of immune cell function as they may pertain to the etiology of autoimmunity.

Selected Publications

Lo B, Ramaswamy M, Davis J, Price S, Rao VK, Siegel RM, Lenardo MJ. A rapid ex vivo clinical diagnostic assay for fas receptor-induced T lymphocyte apoptosis. J Clin Immunol. 2013 Feb;33(2):479-88. doi: 10.1007/s10875-012-9811-z. PubMed Icon

Ramaswamy M, Siegel RM. Autoimmunity: twenty years in the Fas lane. J Immunol. 2012 Dec 1;189(11):5097-100. doi: 10.4049/jimmunol.1202833. PubMed Icon

Meylan F, Richard AC, Siegel RM. TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation. Immunol Rev. 2011 Nov;244(1):188-96. PubMed Icon

Ramaswamy M, Deng M, Siegel RM. Harnessing programmed cell death as a therapeutic strategy in rheumatic diseases. Nat Rev Rheumatol. 2011 Mar;7(3):152-60. PubMed Icon

Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY, Sack MN, Kastner DL, Siegel RM. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med. 2011 Mar 14;208(3):519-33. PubMed Icon

Ramaswamy M, Cruz AC, Cleland SY, Deng M, Price S, Rao VK, Siegel RM. Specific elimination of effector memory CD4(+) T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains. Cell Death Differ 2011 Apr;18(4):712-20. PubMed Icon

Zhang, H.H., K. Song, R.L. Rabin, B.J. Hill, S.P. Perfetto, M. Roederer, D.C. Douek, R.M. Siegel, and J.M. Farber. 2010. CCR2 identifies a stable population of human effector memory CD4(+) T cells equipped for rapid recall response. J Immunol 185:6646-666 PubMed Icon

Dufour, F., A.M. Sasseville, S. Chabaud, B. Massie, R.M. Siegel, and Y. Langelier. (2010)The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8. Apoptosis online, 10.1007/s10495-010-0560-2 PubMed Icon

Meylan F, Song YJ, Fuss I, Villarreal S, Kahle E, Malm IJ, Acharya K, Ramos HL, Lo L, Mentink-Kane MM, Wynn TA, Migone TS, Strober W, Siegel RM. The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. Mucosal Immunology 2011 Mar;4(2):172-85. PubMed Icon

Simon A, Park H, Maddipati R, Lobito AA, Bulua AC, Jackson AJ, Chae JJ, Ettinger R, de Koning HD, Cruz AC, Kastner DL, Komarow H, Siegel RM. Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome. Proc Natl Acad Sci U S A. 2010 May 10. [Epub ahead of print] PubMed PMID: 20457915. PubMed Icon

See extended list of publications


Updated October 12, 2010