Research

Arthritis and Rheumatism Branch

Paul H. Plotz, M.D.
Chief, Arthritis and Rheumatism Branch
Phone: (301) 496-1474
Fax: (301) 402-0012
E-mail: plotzp@mail.nih.gov

The Arthritis and Rheumatism Branch works on basic and clinical aspects of genetic and inflammatory muscle diseases and on basic questions of autoimmunity.


Selected Publications

Douillard-Guilloux G, Raben N, Takikita S, Batista L, Caillaud C, Richard E. Modulation of glycogen synthesis by RNA interference: towards a new therapeutic approach for glycogenosis type II. Hum Mol Genet. 2008 Dec 15;17(24):3876-86. Epub 2008 Sep 9. PubMed Icon

Raben N, Hill V, Shea L, Takikita S, Baum R, Mizushima N, Ralston E, Plotz P. Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. Hum Mol Genet. 2008 Dec 15;17(24):3897-908. Epub 2008 Sep 9. PubMed Icon

Fukuda, T., Ahearn, M., Roberts, A., Mattaliano, RJ, Zaal, K, Ralston, E, Plotz, PH, & Raben, N. Autophagy and mistargeting of therapeutic enzyme in skeletal muscle in Pompe Disease. Mol. Ther. Epub 2006 Sep 26. PubMed Icon

Plotz PH. The autoantibody repertoire: searching for order. Nat Rev Immunol. 2003; 3(1):73-8. Review. PubMed Icon

Raben N, Jatkar T, Lee A, Lu N, Dwivedi S, Nagaraju K, Plotz PH. Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme. Mol Ther. 2002 Nov;6(5):601-8. PubMed Icon

See complete list of publications

 

Updated November 20, 2009