How Is Paget’s Disease of Bone Diagnosed?

January 2012

Symptoms of Paget’s Disease

Many people with Paget’s disease do not know they have it. There may be no symptoms, or the symptoms may be very mild. Sometimes the symptoms are mistaken for something else, such as arthritis. In other cases, complications, which vary depending on which bones are affected, have developed before Paget’s disease is diagnosed.

Methods Used to Diagnose Paget’s Disease

Three tests—an x ray, blood test, and bone scan—are commonly used to discover Paget’s disease. Sometimes the disease is found by accident when one of these tests is done for another reason. X rays are used to make the final diagnosis. On rare occasions, a fourth test called a bone biopsy also may be used to confirm the diagnosis.

X rays. In x-ray images, bones affected by Paget’s disease have a particular appearance that is different from other bones. Accordingly, a doctor will use x rays, alone or with a blood test or bone scan, to confirm whether or not a person has Paget’s disease of bone.

Blood test (measurement of serum alkaline phosphatase). Sometimes blood test results are what first alert doctors to the possibility that a person has Paget’s disease. When blood contains a higher-than-usual level of a chemical substance called serum alkaline phosphatase (SAP), it is a sign that the disease may be present.

SAP is a type of enzyme made by bone cells that is overproduced by pagetic bone. The SAP level for someone age 60 or older typically ranges from 20 to 120 units, depending on the testing laboratory used.

A mild increase in SAP, up to twice the usual level, may indicate Paget’s disease or another condition, such as liver disease or a bone fracture that is in the process of healing. However, a SAP level greater than twice the usual level strongly suggests Paget’s disease, especially if the person’s serum calcium level, phosphorus level, and kidney function are normal.

Siblings and children of someone with Paget’s disease may decide to have a SAP test annually after the age of 40 to rule out the possibility that they have inherited the disease. In addition, after diagnosis, measurements of SAP levels are used to track how well a person with Paget’s disease is responding to treatment.

Bone scan. A bone scan is a test that helps identify which bones have been affected by Paget’s disease. The procedure is also a useful way to determine the extent and activity of the disease. In a bone scan, a safe amount of a radioactive substance is injected into the person’s vein. The substance circulates through the bloodstream and "highlights" places in the skeleton where Paget’s disease may be present. If the scan suggests that the person has the disease, the affected areas usually are x rayed to confirm the diagnosis.

Bone biopsy. In rare cases, a biopsy (a small sample of tissue removed for analysis) is taken from bone that is suspected of having Paget’s disease. Bone biopsies are done when x-ray images do not confirm the presence or absence of the disease.

Urine test. Although urine tests are not used to detect or diagnose Paget’s disease, they may be used to monitor a person’s response to treatment for the disease. In this test, a sample of the person’s urine is analyzed for the presence of substances called bone markers. These substances provide information about bone resorption—the process of breaking down and taking up of bone by the body. One such substance is N-telopeptide.

After the Diagnosis

Several effective treatment options are available for people who are diagnosed with Paget’s disease. Information on these treatments is available from the NIH Osteoporosis and Related Bone Diseases ~ National Resource Center.

Resource

For more information about Paget’s disease, contact:

The Paget Foundation for Paget’s Disease of Bone and Related Disorders

Website: http://www.paget.org

The National Institutes of Health Osteoporosis and Related Bone Diseases ~
National Resource Center acknowledges the assistance of the Paget Foundation for Paget’s Disease of Bone and Related Disorders in the preparation of this publication.

For Your Information

This publication contains information about medications used to treat the health condition discussed here. When this publication was produced, we included the most up-to-date (accurate) information available. Occasionally, new information on medication is released.

For updates and for any questions about any medications you are taking, please contact:

U.S. Food and Drug Administration

Website: http://www.fda.gov
Toll free: 888–INFO–FDA (888–463–6332)


For additional information on specific medications, visit Drugs@FDA at www.accessdata.fda.gov/scripts/cder/drugsatfda. Drugs@FDA is a searchable catalog of FDA-approved drug products.

For updates and questions about statistics, please contact:

Centers for Disease Control and Prevention’s National Center for Health Statistics

Website: http://www.cdc.gov/nchs
Toll free: 800–232–4636

NIH Osteoporosis and Related Bone Diseases ~ National Resource Center

2 AMS Circle
Bethesda, MD 20892-3676
Phone: 202-223-0344
Toll Free: 800-624-BONE (2663)
TTY: 202-466-4315
Fax: 202-293-2356
Email: NIHBoneInfo@mail.nih.gov
Website: http://www.bones.nih.gov

The NIH Osteoporosis and Related Bone Diseases ~ National Resource Center provides patients, health professionals, and the public with an important link to resources and information on metabolic bone diseases. The mission of NIH ORBD~NRC is to expand awareness and enhance knowledge and understanding of the prevention, early detection, and treatment of these diseases as well as strategies for coping with them.

The NIH Osteoporosis and Related Bone Diseases ~ National Resource Center is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases with contributions from:

The National Institutes of Health (NIH) is a component of the U.S. Department of Health and Human Services (HHS).

Most of our bone publications are available online only. Some are available in print. Would you like to order publications on bone disorders to be mailed to you? Visit our online order form.