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Multidisciplinary Clinical Research Centers
Updated December 2012
The Multidisciplinary Clinical Research Centers (MCRC) (P60) address critical issues directly relevant to the prevention, assessment and improvement of clinical outcomes for patients with arthritis and musculoskeletal and skin diseases. Each center is organized around a Methodology Core which provides key support for clinical projects within and outside the MCRC. The projects listed below were funded through RFA-AR-07-001 or RFA-AR-12-001.
MULTIDISCIPLINARY CLINICAL RESEARCH CENTER at Boston University Medical Campus
Principal Investigator: Felson, David T.
Project start date: September 2001
Funded through: July 2017
Current subprojects:
- Massive Weight Loss and Its Effects on Knee Pain and Knee Structure
- Central Sensitization in Post-Knee Replacement Pain and Relation to Osteoarthritis Pathology
- Methodology Core
MULTIDISCIPLINARY CLINICAL RESEARCH CENTER at Brigham and Women’s Hospital
Principal Investigator: Katz, Jeffrey N.
Project start date: June 2001
Funded through: June 2017
Current subprojects:
- Rheumatic Expertise Expanded Access to Improve Community Health (REACH-RA)
- Communication of Biomarker, Genetic, Lifestyle Risk Factor Profiles for Rheumatoid Arthritis to First Degree Relatives
- Methodology Core
MULTIDISCIPLINARY CLINICAL RESEARCH CENTER at Children's Hospital Medical Center in Cincinnati
Principal Investigator: Lovell, Daniel J.
Project start date: September 2001
Funded through: July 2013
Current subprojects:
- Improved Diagnostics and Advanced Magnetic Resonance Imaging for Pediatric Neuropsychiatric Systemic Lupus Erythematosus
- Improved Understanding of the Biology and Use of the Tumor Necrosis Factor Inhibition in Juvenile Idiopathic Arthritis
- Macrophage Activation Syndrome Biomarkers in Systemic Juvenile Idiopathic Arthritis
- Determinants of Health Related Quality of Life in Children with Juvenile Idiopathic Arthritis
- Methodology Core
MULTIDISCIPLINARY CLINICAL RESEARCH CENTER at Dartmouth College
Principal Investigator: Tosteson, Anna N.
Project start date: September 2012
Funded through: August 2017
Current subprojects:
- Optimizing Fracture Care Outcomes: A Comparative Effectiveness Approach
- Outcomes Calculators For Informed Decision Making in Back Surgery
- Evaluating Safety of Emerging Orthopaedic Technologies
- Methodology Core
MULTIDISCIPLINARY CLINICAL RESEARCH CENTER FOR RHEUMATIC DISEASES IN AFRICAN AMERICANS at the Medical University of South Carolina
Principal Investigator: Gilkeson, Gary S.
Project start date: July 2012
Funded through: June 2017
Current subprojects:
- Defective c-Met Signaling in African American Scleroderma Patients
- Genetic and Environmental Influences on Systemic Lupus Erythematosus and Lupus-Related Autoimmunity
- Methodology Core
- Patient Resource Core
MULTIDISCIPLINARY CLINICAL RESEARCH CENTER at the University of Alabama at Birmingham
Principal Investigator: Kimberly, Robert P.
Project start date: March 2002
Funded through: June 2013
Current subprojects:
- Improving Care of Osteoporosis: Multi-Modal Interventions to Increase Testing and Treatment (ICOMMIITT)
- Genetic and Molecular Markers of Methotrexate Efficacy and Toxicity in Early Rheumatoid Arthritis
- Predictors of Rheumatoid Arthritis Severity in African Americans
- Methodology Core
MULTIDISCIPLINARY CLINICAL RESEARCH CENTER at the University of California, San Francisco
Principal Investigator: Yelin, Edward H.
Project start date: January 2006
Funded through: April 2017
Current subprojects:
- Genetics, Ancestry and Systemic Lupus Erythematosus Outcomes
- Health Care Factors Affecting Outcomes of Vulnerable Populations with Systemic Lupus Erythematosus
- The Development of a Tailored Symptom Assessment Tool to Enhance Patient-Centered Care in Rheumatoid Arthritis
- Methodology Core
MULTIDISCIPLINARY CLINICAL RESEARCH CENTER at Vanderbilt University Medical Center
Principal Investigator: Stein, Charles M.
Project start date: September 2008
Funded through: July 2013
Current subprojects:
